Title

ANTIMICROBIAL ACTIVITY OF GOOSEGRASS (Eleusine indica) PARTS (ROOTS, STEMS, AND LEAVES) AGAINST Escherichia coli AND Staphylococcus aureus

Author(s)

BALDERAMA, PRINCESS HYACINTH P.

CHUPUICO, NONA ROSE G.

MOLDE, DIVINE GRACE V.

Affiliation

Misamis University - College of Medical Technology

Contributor

Guiaman, Shaira Alain U. - Adviser

Villantes, Yunalyn L. - Panel

Lao, Karl Maxel O. - Panel

Atty. Awa, Anthony L. - Panel

Year

2025-05

Abstract

The increasing prevalence of antibiotic resistance has underscored the urgent need for alternative antimicrobial therapies. This study investigated the antimicrobial efficacy of Eleusine indica, a traditionally used medicinal plant, against Escherichia coli and Staphylococcus aureus. This research aimed to assess the antimicrobial properties of E. indica extracts at different concentrations (50%, 70%, and 100%) and compare their effectiveness with conventional antibiotics. The study utilized a laboratory-based experimental design, measuring the inhibition zones to evaluate the plant extracts' microbial activity. Results showed that tetracycline exhibited the most potent antimicrobial activity, with significant inhibition zones observed against both bacterial strains. Among the E. indica extracts, the stem extract exhibited moderate antimicrobial effects, especially at the 100% concentration, where it demonstrated an 11 mm inhibition zone against E. coli and 2 mm against S. aureus. However, higher concentrations (70%) of the plant extracts were less effective, indicating that further optimization in extraction techniques is necessary. The findings suggest that E. indica has promising potential as an alternative antimicrobial agent. Further research is required to isolate and identify the specific bioactive compounds responsible for these effects and evaluate their safety and toxicity profiles for potential pharmaceutical development.

Keywords

antimicrobial agents

antibiotic resistance

medicinal plants

plant extracts

traditional medicine